Early age at natural menopause is related to lower post-bronchodilator lung function: A longitudinal population-based study

B Campbell; DS Bui; JA Simpson; CJ Lodge; AJ Lowe; G Bowatte; B Leynaert; FG Real; PS Thomas; GG Giles; DP Johns; J Garcia-Aymerich; JL Hopper; D Jarvis; MJ Abramson; EH Walters; JL Perret; SC Dharmage

Journal article

Early age at natural menopause is related to lower post-bronchodilator lung function: A longitudinal population-based study

B Campbell, DS Bui, JA Simpson, CJ Lodge, AJ Lowe, G Bowatte, B Leynaert, FG Real, PS Thomas, GG Giles, DP Johns, J Garcia-Aymerich, JL Hopper, D Jarvis, MJ Abramson, EH Walters, JL Perret, SC Dharmage

Annals of the American Thoracic Society | AMER THORACIC SOC | Published : 2020

DOI: 10.1513/AnnalsATS.201902-180OC

Abstract

Rationale: Poor lung function, a significant predictor of mortality, has been observed in postmenopausal women compared with those still menstruating. Menopausal age is a risk factor for several adverse health outcomes, but little evidence exists on the impact of menopausal age on lung function impairments, especially regarding post-bronchodilator lung function measures. Objectives: To investigate the association between age atmenopause and pre- and post-bronchodilator lung function outcomes. Methods: During the sixth-decade follow-up of the Tasmanian Longitudinal Health Study cohort (mean age, 53 yr), information was collected on most recent menstrual period and menopausal status. Lung func..

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University of Melbourne Researchers

Dinh Bui Author

Julie Simpson Author

Caroline Lodge Author

Adrian Lowe Author

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Grants

Awarded by Royal Hobart Hospital Research Foundation

Funding Acknowledgements

Supported by the National Health and Medical Research Council (NHMRC) of Australia under NHMRC project grant schemes 299901 and 1021275 and NHMRC European collaborative grant scheme 1101313 as part of the Ageing Lungs in European Cohorts (ALEC) program funded by the European Union's Horizon 2020 research and innovation program under grant agreement 633212, the University of Melbourne, the Clifford Craig Medical Research Trust of Tasmania, the Asthma Foundation of Victoria, the Asthma Foundation of Queensland, the Asthma Foundation of Tasmania, the Royal Hobart Hospital, the Helen MacPherson Smith Trust, and GlaxoSmithKline. The funding agencies had no direct role in the conduct of the study; the collection, management, statistical analysis, and interpretation of the data; or the preparation or approval of the manuscript. J.A.S., C.J.L., A.J.L., and S.C.D. are funded by NHMRC fellowships.